BindingDB BDBM50240772 (1R,2S)-(-)-2-phenylcyclopropylamine::(1R,2S)-2-phenylcyclopropanamine::(tranylcypromine)2-Phenyl-cyclopropylamine::2-Phenyl-cyclopropylamine::CHEMBL1179::Parnate::TRANYLCYPROMINE::TRANYLCYPROMINE HYDROCHLORIDE::US10836743, Compound TCP::US8993808, Tranylcypromine::US9180183, Tranylcypromine::cid_2723716::rel-Tranylcypromine

BDBM50240772 (1R,2S)-(-)-2-phenylcyclopropylamine::(1R,2S)-2-phenylcyclopropanamine::(tranylcypromine)2-Phenyl-cyclopropylamine::2-Phenyl-cyclopropylamine::CHEMBL1179::Parnate::TRANYLCYPROMINE::TRANYLCYPROMINE HYDROCHLORIDE::US10836743, Compound TCP::US8993808, Tranylcypromine::US9180183, Tranylcypromine::cid_2723716::rel-Tranylcypromine

SMILES N[C@@H]1C[C@H]1c1ccccc1

InChI Key InChIKey=AELCINSCMGFISI-DTWKUNHWSA-N

Data 15 KI 84 IC50 4 Kd 2 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50240772

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 5.00E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 1.90E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomeMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in insect microsomesMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair

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Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 3.10E+3nMAssay Description:Inhibition of human recombinant CYP2C19 using CEC as substrate incubated for 50 mins by fluorimetryMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 3.04E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 5.95E+3nMAssay Description:Inhibition of human CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 1.03E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephentoin as substrate after 5 to 15 minsMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 2.80E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 2.80E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 2.07E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using omeprazole as substrate incubated for 5 mins followed by NADPH addition and measured after 20 m...More data for this Ligand-Target Pair

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 5.86E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 9.25E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using Mephenytoin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair

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B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 1.17E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsome using mephenytoin as substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 1.44E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate and measured by LC-MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Cytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent

PNG

BDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)

IC50: 1.44E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Filter my 105 hits

Targets 23▿
- Lysine-specific histone demethylase 1A 24
- Cytochrome P450 2C19 19
- Amine oxidase [flavin-containing] B 14
- Amine oxidase [flavin-containing] A 13
- Cytochrome P450 2B6 10
- Lysine-specific histone demethylase 2 2
- Cytochrome P450 2A13 2
- Alpha-1A adrenergic receptor 2
- Lysine-specific histone demethylase 1A/REST corepressor 1 2
- Guanine nucleotide-binding protein subunit alpha-15 2
- Trace amine-associated receptor 1 2
- Cytochrome P450 2A6 2
- Lysine-specific demethylase 4E 1
- D(3) dopamine receptor 1
- Sigma intracellular receptor 2 1
- Sigma non-opioid intracellular receptor 1 1
- Lysine-specific histone demethylase 1A/REST corepressor 3 1
- Lysine-specific demethylase 6B 1
- Lysine-specific demethylase 2A 1
- Lysine-specific demethylase 4C 1
- Lysine-specific demethylase 5C 1
- Lysine-specific demethylase 3A 1
- Bile salt export pump 1
- ...
Publications 50▿
- J Med Chem 57: 42-55 (2014) 9
- J Med Chem 60: 1673-1692 (2017) 5
- J Med Chem 62: 10124-10143 (2019) 4
- J Med Chem 62: 1246-1273 (2019) 4
- J Med Chem 58: 1705-16 (2015) 4
- Drug Metab Dispos 40: 1797-802 (2012) 4
- Bioorg Med Chem Lett 28: 167-169 (2018) 3
- Bioorg Med Chem Lett 29: 844-847 (2019) 3
- Eur J Med Chem 94: 163-74 (2015) 3
- J Med Chem 63: 14197-14215 (2020) 3
- J Med Chem 56: 8543-60 (2013) 3
- Bioorg Med Chem 26: 775-785 (2018) 3
- Bioorg Med Chem Lett 29: 544-548 (2019) 3
- US Patent US8993808 (2015) 3
- US Patent US9180183 (2015) 2
- US Patent US10836743 (2020) 2
- J Med Chem 51: 5064-74 (2008) 2
- J Med Chem 54: 2307-19 (2011) 2
- J Med Chem 51: 8077-87 (2008) 2
- J Med Chem 54: 534-47 (2011) 2
- Mol Pharmacol 13: 454-73 (1977) 2
- Eur J Med Chem 148: 210-220 (2018) 2
- Bioorg Med Chem 28: (2020) 2
- J Med Chem 51: 6138-49 (2008) 2
- J Med Chem 47: 1796-806 (2004) 1
- Eur J Med Chem 195: (2020) 1
- J Med Chem 56: 9496-508 (2014) 1
- Bioorg Med Chem Lett 28: 1001-1004 (2018) 1
- J Med Chem 59: 1308-29 (2016) 1
- J Med Chem 57: 4962-8 (2014) 1
- PubChem Bioassay (2013) 1
- Bioorg Med Chem 19: 3625-36 (2011) 1
- PubChem Bioassay (2013) 1
- PubChem Bioassay (2013) 1
- Eur J Med Chem 187: (2020) 1
- PubChem Bioassay (2013) 1
- J Med Chem 63: 9316-9339 (2020) 1
- Eur J Med Chem 225: (2021) 1
- J Med Chem 64: 17123-17145 (2021) 1
- Eur J Med Chem 200: (2020) 1
- Eur J Med Chem 213: (2021) 1
- Bioorg Med Chem Lett 24: 4271-5 (2014) 1
- Eur J Med Chem 240: (2022) 1
- Bioorg Med Chem 27: 370-374 (2019) 1
- J Med Chem 47: 5860-71 (2004) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- ACS Med Chem Lett 11: 1213-1220 (2020) 1
- Bioorg Med Chem 19: 3709-16 (2011) 1
- Eur J Med Chem 240: (2022) 1
- ACS Med Chem Lett 8: 321-326 (2017) 1
- ...
Institutions 38▿
- Sapienza University Of Rome 12
- Saarland University 10
- Zhengzhou University 8
- European Institute Of Oncology 5
- University Of Kansas 4
- The Scripps Research Institute Molecular Screening Center 4
- University Of Texas Southwestern 4
- Recordati 4
- Taizhou People'S Hospital 3
- Waseda University 3
- Key Laboratory Of Henan Provinc 3
- Universit£T M£Nster 3
- Kyoto Prefectural University Of Medicine 3
- Oryzon Genomics 3
- Liaoning Shihua University 3
- Medical University Of South Carolina 2
- TBA 2
- Shanghai Institute of Material Medica, Chinese Academy of Sciences 2
- Henan University Of Chinese Medicine 2
- Telormedix 2
- Anhui Medical University 1
- China Pharmaceutical University 1
- Peking Union Medical College And Chinese Academy Of Medical Sciences 1
- Wuhan University 1
- National Institute Of Diabetes And Digestive And Kidney Diseases 1
- University Of Oxford 1
- University Of Copenhagen 1
- Constellation Pharmaceuticals 1
- Global Blood Therapeutics 1
- University Of Michigan 1
- Cardiff University 1
- Chinese Academy Of Medical Sciences & Peking Union Medical College 1
- Astrazeneca 1
- Alma Mater Studiorum-University Of Bologna 1
- University Of Southampton 1
- Lomonosov Moscow State University 1
- University Of Utah 1
- Chung-Ang University 1
- ...
Affinity: 9.4 to 1.0E+6 nM▿
- Ki 15
- IC50 84
- Kd 4
- EC50 2
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1